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Breast Tissue Microenvironment

Meaning

The breast tissue microenvironment is the complex, dynamic milieu surrounding the mammary epithelial cells, comprising the extracellular matrix, fibroblasts, adipocytes, immune cells, and local signaling molecules. This environment is critically involved in regulating normal breast development, tissue remodeling, and the initiation and progression of both benign and malignant disease states. Its composition and signaling capacity are highly sensitive to systemic hormonal fluctuations and local metabolic cues, serving as a critical mediator of hormonal effects. Assessing this environment provides essential context for breast health and risk stratification.