What is the Origin of Brain Protection Hormones?

This terminology arose from the expanding field of neuroendocrinology, recognizing that steroid hormones synthesized in the gonads and adrenal glands also function locally in the brain. The term 'protection' highlights their role in maintaining neural integrity, a function distinct from their classical reproductive roles. Clinical research increasingly focuses on these hormones' potential to mitigate age-related cognitive decline.

What is the Mechanism of Brain Protection Hormones?

The neuroprotective mechanism is multifaceted, involving both genomic and non-genomic actions. These hormones can modulate the expression of genes related to antioxidant enzymes and anti-inflammatory cytokines. Non-genomically, they interact with cell surface receptors, such as GABA-A receptors, to regulate neuronal excitability and maintain cellular energy balance. This dual action helps stabilize synaptic function and promote the survival of neural networks.

Brain Protection Hormones ∞ Area

Brain Protection Hormones

Meaning

Brain Protection Hormones is a clinical grouping for endogenous steroid hormones, particularly neurosteroids like DHEA, progesterone, and estrogens, that exert significant neuroprotective effects within the central nervous system. These hormones actively shield neurons from damage caused by oxidative stress, inflammation, and excitotoxicity. They are crucial modulators of brain resilience and cognitive longevity.