Brain-Derived Neurotrophic Factor Upregulation

Meaning

Upregulation of BDNF signifies an increase in the synthesis and secretion of this crucial neurotrophin, which supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. In clinical contexts, this enhancement is often associated with improved synaptic plasticity and neurogenesis, particularly in the hippocampus. Maintaining sufficient BDNF levels is fundamental to resilient neural architecture.

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