Specific food matrices and isolated nutrients recognized for their capacity to promote neurological quiescence and reduce excitatory signaling within the central nervous system. These dietary components facilitate the synthesis and function of inhibitory neurotransmitters, such as Gamma-Aminobutyric Acid (GABA). They are clinically employed to support the management of hyper-arousal states and improve sleep latency and quality.
Origin
This concept is rooted in the traditional understanding of food as medicine, scientifically formalized by modern neuropharmacology and nutritional biochemistry. The identification of specific psychoactive nutrients began with the discovery of essential amino acids and their roles as neurotransmitter precursors in the mid-20th century.
Mechanism
These foods supply key cofactors and precursors, including magnesium, tryptophan, and specific polyphenols, necessary for the production of calming neurochemicals. Tryptophan, for example, is the precursor to serotonin, which is then converted to melatonin, regulating sleep-wake cycles. Additionally, certain foods contain compounds that directly or indirectly modulate GABA receptors, thereby enhancing inhibitory neurotransmission and promoting relaxation.
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