Skip to main content

Brain Aging Trajectory

Meaning

The Brain Aging Trajectory defines the chronological and functional progression of changes that occur in the central nervous system over an individual’s lifespan. This trajectory is a highly individualized curve that reflects the rate of cognitive decline, structural atrophy, and underlying neurochemical shifts, all significantly modulated by hormonal balance and lifestyle factors. A favorable trajectory is characterized by preserved cognitive function and minimal structural loss well into advanced age, indicating a robust neurological reserve. Clinically, analyzing this trajectory helps identify individuals at risk for accelerated neurodegeneration and cognitive impairment.