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Brain Aging Mechanisms

Meaning

Brain aging mechanisms are the complex cellular and molecular processes that contribute to the progressive decline in neurological structure and function over an organism’s lifespan. These mechanisms include the accumulation of oxidative stress, chronic neuroinflammation, mitochondrial dysfunction, and the gradual loss of synaptic integrity. Hormonal shifts, such as the decline in estrogen, progesterone, and testosterone, are considered significant accelerators of these age-related changes. Understanding these underlying processes is paramount for developing effective neuroprotective and longevity interventions.