Brain Aging Deceleration is the clinical and physiological objective of slowing the progressive decline in cognitive function, neuronal plasticity, and structural integrity of the central nervous system associated with chronological aging. This is not merely preventing disease but actively optimizing neurobiological health to maintain peak performance for longer. Interventions are often focused on neurotrophic support and managing systemic inflammation.
Origin
This term arises from the intersection of neuroscience, gerontology, and preventative medicine, shifting the focus from treating neurodegenerative disease to proactive maintenance of cognitive reserve. The concept is intrinsically linked to the search for anti-aging strategies.
Mechanism
Deceleration is mediated by preserving mitochondrial function within neurons and promoting neurogenesis, particularly in the hippocampus. Hormones, including estrogens, testosterone, and DHEA, act as neuroprotectors by modulating synaptic density and reducing oxidative stress within the brain parenchyma. The mechanism relies heavily on the integrity of the blood-brain barrier and the efficiency of the glymphatic system for metabolic waste clearance.
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