BPC157, or Body Protection Compound 157, is a synthetic peptide chain composed of 15 amino acids, initially isolated from human gastric juice. This stable pentadecapeptide is currently under investigation for its potential cytoprotective and regenerative properties across various organ systems. Clinical interest focuses on its capacity to promote tissue healing, modulate inflammatory responses, and maintain gastrointestinal tract integrity. It represents a promising area within regenerative medicine for enhancing the body’s natural repair mechanisms.
Origin
The peptide’s sequence is derived from a small segment of the body’s natural gastric juice protein, which plays a crucial role in maintaining mucosal health. Researchers first identified this specific stable gastric pentadecapeptide in the 1990s, recognizing its unique stability and profound biological effects. Its development as a therapeutic agent stems from its potent native role in protecting and repairing the stomach lining.
Mechanism
The mechanism of action involves multiple pathways, primarily through the upregulation of growth factors, such as Vascular Endothelial Growth Factor (VEGF), which facilitates angiogenesis and tissue repair. Furthermore, BPC157 has demonstrated the ability to modulate the Nitric Oxide (NO) system, contributing to its cytoprotective and anti-inflammatory effects throughout the body. This compound appears to stabilize the F-actin cytoskeleton in cells and promote the survival of cells under oxidative stress conditions.
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