The specific therapeutic application of the stable gastric pentadecapeptide BPC-157 to enhance and restore the integrity and function of the brain’s microvasculature. This includes promoting angiogenesis, the formation of new blood vessels, and ensuring robust blood flow to neural tissues. Optimized neurovascularity is critical for delivering oxygen and nutrients, while also efficiently clearing metabolic waste products from the central nervous system. The focus is on supporting the neurovascular unit, which is essential for brain health and repair.
Origin
The term combines the specific peptide name, BPC-157, which was initially studied for its gastrointestinal protective effects, with the neuroscientific concept of ‘neurovascularity.’ Research rapidly expanded to its systemic and central nervous system effects due to its potent regenerative properties observed across multiple tissue types. Its clinical relevance emerged from studies showing its protective role in models of brain injury and ischemia.
Mechanism
BPC-157’s action is thought to involve the upregulation of growth factors, particularly Vascular Endothelial Growth Factor (VEGF), which is a powerful stimulator of angiogenesis. The peptide also exhibits anti-inflammatory effects, stabilizing endothelial cells and reducing damage to the blood-brain barrier. By promoting the structural and functional integrity of the cerebral vasculature, BPC-157 facilitates optimal cerebral perfusion and supports the repair processes following neurological insult or age-related vascular compromise.
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