Refers to the specific neuroprotective and neuromodulatory actions of the stable gastric pentadecapeptide BPC-157 within the central and peripheral nervous systems. This includes its therapeutic potential in mitigating neurological damage, promoting nerve regeneration, and modulating neurotransmitter systems. Clinical interest focuses on its pleiotropic effects on neuronal survival and functional recovery following various insults.
Origin
The peptide BPC-157 was originally isolated from human gastric juice, with its name reflecting its Body Protecting Compound properties across multiple organ systems. The ‘Neurological’ modifier specifies the application and study of this compound within the domain of neuroscience and neuroendocrinology. Its therapeutic potential in nervous tissue repair has driven significant preclinical research.
Mechanism
The neurological action is primarily mediated by its influence on the growth hormone-prolactin axis and its interaction with the nitric oxide (NO) system, promoting angiogenesis and neurotrophic factor expression. It is known to stabilize the gut-brain axis, reducing systemic inflammation that often contributes to neurodegeneration. Furthermore, BPC-157 has demonstrated a capacity to accelerate peripheral nerve healing by promoting axonal outgrowth and myelin sheath formation.
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