BPC-157 is a synthetic, stable gastric pentadecapeptide, comprising 15 amino acids, which is being studied for its significant regenerative and cytoprotective properties. It is often clinically referred to as a ‘Healing Factor’ due to its demonstrable ability to accelerate tissue repair across multiple organ systems, including muscle, tendon, ligament, and the gastrointestinal tract. This compound represents a novel approach to modulating endogenous repair processes and mitigating inflammation at the site of injury.
Origin
The peptide BPC-157 was originally isolated from human gastric juice, with its acronym standing for Body Protection Compound. Its discovery stems from research into the gastrointestinal tract’s intrinsic capacity for mucosal defense and repair. The subsequent synthetic stabilization and study of the pentadecapeptide structure established its clinical relevance far beyond the digestive system, including applications in systemic regeneration.
Mechanism
The mechanism of action is multifaceted, involving the modulation of multiple signaling pathways critical for tissue homeostasis and angiogenesis. BPC-157 is known to promote the survival of cells under stress and enhance the expression of growth factors, such as Vascular Endothelial Growth Factor (VEGF), facilitating new blood vessel formation. Furthermore, it interacts with the nitric oxide system and demonstrates significant anti-inflammatory and antioxidant effects, collectively driving a systemic repair command.
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