This term refers to the clinical and physiological relationship between the essential trace mineral Boron and its modulating influence on circulating testosterone levels and its bioavailability. Boron is not a hormone itself but acts as a cofactor or modulator within the endocrine system, specifically affecting the metabolism of steroid hormones. Research suggests that adequate Boron intake may support healthy hormonal balance, particularly by potentially increasing the fraction of free, biologically active testosterone.
Origin
The connection between Boron and steroid hormones began to be explored in nutritional and endocrinological research in the late 20th century, following observations of its essential role in bone health and mineral metabolism. The specific focus on its interaction with testosterone emerged from studies investigating nutritional factors that influence the endocrine profiles of men and women. This area of study continues to define the mineral’s role as an important endocrine-supporting nutrient.
Mechanism
Boron’s proposed mechanism involves two primary pathways: first, it may reduce the circulating levels of Sex Hormone-Binding Globulin (SHBG), which consequently increases the concentration of free testosterone available to target cells. Second, it is hypothesized to inhibit the enzyme aromatase, thereby limiting the peripheral conversion of testosterone into estradiol. This dual action functions to optimize the testosterone-to-estrogen ratio, supporting overall androgenic effect and bioavailability.
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