Question 1

What is the Meaning of Bone-Muscle Crosstalk?

Accepted Answer

Bone-Muscle Crosstalk is the complex, bidirectional signaling network between skeletal muscle and bone tissue, where each organ influences the other's structural integrity, development, and metabolism. This reciprocal communication is essential for maintaining musculoskeletal health, functional mobility, and preventing age-related conditions like sarcopenia and osteoporosis. It represents a unified physiological system where mechanical and biochemical signals are seamlessly integrated.

Question 2

What is the Origin of Bone-Muscle Crosstalk?

Accepted Answer

The recognition of this inter-organ communication emerged from clinical observations in endocrinology and orthopedics, noting that mechanical forces from muscle contraction are powerful stimuli for bone adaptation. The term 'crosstalk' is a biological metaphor that precisely describes the continuous, two-way exchange of regulatory signals between distinct cell populations.

Question 3

What is the Mechanism of Bone-Muscle Crosstalk?

Accepted Answer

Mechanical loading from muscle contraction exerts a direct physical strain on the bone, stimulating osteocytes to initiate bone remodeling and formation. Biochemically, muscle tissue releases various signaling molecules, known as myokines, such as Irisin, which can exert paracrine and endocrine effects on bone metabolism. Simultaneously, bone-derived hormones like osteocalcin act on muscle tissue, enhancing glucose uptake and promoting muscle function, thereby closing the crucial regulatory loop.

Bone-Muscle Crosstalk

Meaning

Origin

Mechanism

What Molecular Pathways Do Lifestyle Interventions Activate for Bone Health?

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