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Bone Marrow Microenvironment

Meaning

The bone marrow microenvironment is the specialized anatomical niche within the medullary cavity of bones, comprising cellular and non-cellular components that are crucial for hematopoiesis and skeletal integrity. This intricate ecosystem includes mesenchymal stem cells, adipocytes, endothelial cells, immune cells, and the extracellular matrix, all interacting to support the development of blood cells. It acts as a primary regulatory center, responding dynamically to systemic signals, including those from the endocrine system. The health of this microenvironment is intrinsically linked to immune function and bone density, both of which are highly sensitive to hormonal fluctuations.