What is the Origin of Bone-Brain Axis?

The term emerged from groundbreaking research that identified osteocalcin, a hormone secreted by bone-forming osteoblasts, as a key signaling molecule. This discovery confirmed that the skeletal system actively communicates with the brain, crossing the blood-brain barrier to influence critical neurological processes. This marked a paradigm shift in understanding systemic physiology.

What is the Mechanism of Bone-Brain Axis?

Osteoblasts release hormones, notably osteocalcin, which acts upon receptors in the brain to modulate neurotransmitter synthesis, enhance mitochondrial function in neurons, and positively influence memory and behavior. Conversely, the brain, through the sympathetic nervous system and various endocrine factors, regulates the processes of bone remodeling, density, and overall skeletal integrity.

Bone-Brain Axis

Meaning

The Bone-Brain Axis describes a scientifically validated, bidirectional communication system that illustrates the reciprocal regulatory influence between skeletal tissue and the central nervous system. This axis elevates the skeleton’s role beyond structural support, recognizing it as an active endocrine organ with direct effects on brain function. Disruptions in this communication can impact both bone density and neurocognitive health.