This refers to the deliberate, clinically managed modification of the relative proportions of lean mass, fat mass, and bone density within the human body to optimize endocrine function and overall metabolic health. Specific ratios, such as the waist-to-hip ratio or fat-free mass percentage, are targeted because they directly influence adipokine signaling and sex hormone metabolism. Adjusting these ratios is fundamental to restoring hormonal homeostasis.
Origin
Derived from anthropometry and clinical physiology, the term describes the process of altering body composition metrics, which are recognized as key modulators of endocrine axes. It moves beyond simple weight management to focus on the quality and distribution of mass.
Mechanism
Changes in adipose tissue distribution directly affect aromatase activity, altering the conversion of androgens to estrogens, thereby impacting the HPG axis. Furthermore, lean muscle mass positively influences insulin sensitivity and growth hormone release dynamics. Therefore, targeted ratio adjustment recalibrates systemic metabolic signaling that regulates long-term endocrine output.
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