A clinical strategy focused on decreasing the cumulative level of xenobiotics, heavy metals, and persistent organic pollutants stored within the body’s tissues. This reduction aims to alleviate the chronic physiological stress placed upon detoxification organs, particularly the liver and kidneys. Achieving a lower body burden is critical for restoring optimal endocrine function and cellular integrity.
Origin
The concept stems directly from environmental toxicology and clinical detoxification protocols, acknowledging that modern life exposes the human organism to a constant influx of non-native chemical compounds. It is a fundamental principle in functional medicine, where chronic disease is often linked to the total toxic load exceeding the body’s clearance capacity.
Mechanism
The process relies on supporting the liver’s Phase I (oxidation, reduction, hydrolysis) and Phase II (conjugation) detoxification pathways, facilitating the transformation and excretion of fat-soluble toxins. Key micronutrients and amino acids, such as those required for glutathione synthesis, are utilized to bind and neutralize harmful metabolites. Enhanced gastrointestinal motility and integrity further ensure effective elimination and prevent enterohepatic recirculation of toxicants.
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