Blood viscosity is a measure of the internal friction and resistance to flow within the circulating blood, reflecting its thickness or stickiness. This rheological property is primarily determined by the concentration of red blood cells, plasma protein levels, and the deformability of the erythrocytes. Clinically, maintaining optimal blood viscosity is critical for efficient microcirculation and adequate tissue oxygenation throughout the body. Elevated viscosity can impede flow, increasing the hemodynamic burden on the cardiovascular system.
Origin
The concept originates from the field of rheology, the study of the flow of matter, and its application to human physiology. The understanding of blood as a non-Newtonian fluid dates back to early studies in hemodynamics. The clinical relevance of blood viscosity as a key determinant of cardiovascular risk has become increasingly recognized in modern preventative medicine.
Mechanism
Blood viscosity directly influences the shear stress exerted on the endothelial lining of blood vessels, which is a key regulator of vascular health and nitric oxide production. When viscosity is pathologically high, it can promote sluggish blood flow, increase the risk of thrombosis, and impair the delivery of hormones and nutrients to target tissues. Maintaining appropriate hydration and managing erythrocyte concentration are physiological mechanisms used to regulate this critical parameter.
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