Blood-Brain Barrier Integrity

Meaning

Blood-Brain Barrier Integrity refers to the structural and functional soundness of the highly selective semipermeable border of specialized endothelial cells that separates the circulating blood from the central nervous system (CNS). Maintaining this integrity is absolutely vital for protecting the delicate neural microenvironment from potentially harmful blood-borne substances, pathogens, and toxins. A compromise in this barrier is a significant pathogenic event in many neurodegenerative and inflammatory disorders. This barrier is a critical physiological checkpoint for brain health and cognitive function.

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