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Biomarker Threshold Redefinition

Meaning

Biomarker threshold redefinition is the clinical strategy of adjusting the acceptable reference ranges for specific biochemical indicators to a more physiologically optimal, rather than merely pathological, level. This approach moves beyond simply diagnosing overt disease to proactively managing risk factors and promoting superior health outcomes. The redefinition aims to establish thresholds consistent with peak human performance and longevity, often tightening the limits found in standard population-based lab reports. Implementing this concept requires longitudinal data analysis and personalized clinical judgment to interpret an individual’s unique biochemical profile.