A clinical paradigm focused on extending the period of life spent in good health and free from chronic disease, where therapeutic decisions and lifestyle adjustments are guided and quantified by precise, measurable biological indicators. This approach prioritizes functional longevity over mere chronological lifespan.
Origin
Biomarker is a portmanteau of biological and marker, referring to a measurable indicator of a biological state. Healthspan is a relatively modern term in gerontology, contrasting with lifespan, emphasizing the quality of years lived.
Mechanism
The core mechanism involves longitudinal tracking of a panel of objective clinical biomarkers, which may include measures of inflammation, telomere length, hormone levels, and metabolic parameters. Interventions are continuously titrated based on these data to shift the individual’s physiological state toward optimal, youthful ranges, thereby mitigating age-related decline and extending robust function.
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