A proactive and data-driven clinical strategy focused on influencing the long-term course of an individual’s physiological aging and health status away from pathology and towards optimal function. This management involves continuous monitoring of advanced biomarkers, personalized lifestyle interventions, and targeted therapeutic adjustments. The goal is to steer the individual’s health trajectory to compress morbidity and extend the period of high-quality life.
Origin
This concept is a contemporary evolution of preventive medicine, integrating principles from gerontology, personalized medicine, and systems biology. The “trajectory” metaphor emphasizes the dynamic, time-dependent nature of health, moving beyond static disease treatment to a continuous optimization model. “Management” highlights the systematic, ongoing intervention required to maintain a favorable biological course.
Mechanism
The mechanism operates by utilizing predictive biomarkers to identify early deviations from optimal health, allowing for preemptive intervention before overt disease manifests. This includes modulating key longevity pathways, optimizing hormonal balance, and improving cellular metabolism through precise nutritional and pharmacological strategies. By consistently addressing the root causes of dysfunction, the process works to maintain physiological reserve and slow the rate of age-related decline.
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