A conceptual framework in longevity science and endocrinology that focuses on therapeutically altering or decelerating the rate of biological aging, rather than chronological aging. This involves targeted interventions aimed at restoring youthful epigenetic and physiological function at the cellular and systemic level. The objective is to shift the body’s internal, age-related metrics toward a healthier, earlier stage of the life cycle, optimizing hormonal and metabolic profiles.
Origin
The term combines ‘Biological Timeline,’ referring to the body’s intrinsic aging process measured by biomarkers, and ‘Rewriting,’ suggesting an active, programmatic intervention. Its conceptual roots lie in the fields of gerontology, epigenetics, and advanced regenerative medicine, gaining clinical traction within precision hormonal health.
Mechanism
The mechanism centers on modulating key longevity pathways, such as sirtuins, mTOR, and AMPK, which govern cellular stress response and repair. This modulation often involves exogenous hormonal support, specific nutraceuticals, and lifestyle adjustments designed to influence DNA methylation patterns and telomere stability. The goal is to correct age-related endocrine decline and enhance cellular repair kinetics, effectively reprogramming the body’s functional biological age.
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