What is the Origin of Biological Time Deceleration?

This terminology is rooted in the field of biogerontology, evolving from the understanding that aging is not merely the passage of time but a quantifiable biological process. The 'biological clock' metaphor provides the framework, while the 'deceleration' aspect signifies an active intervention or lifestyle factor successfully pushing the biological age younger than the chronological age. It represents a paradigm shift toward measuring and manipulating the speed of aging.

What is the Mechanism of Biological Time Deceleration?

Deceleration is achieved by targeting fundamental aging pathways, including cellular senescence, mitochondrial dysfunction, and epigenetic drift. Interventions often focus on optimizing metabolic signaling pathways like mTOR and AMPK, enhancing DNA repair mechanisms, and reducing oxidative stress. By improving cellular resilience and turnover, the overall rate of systemic damage accumulation is reduced, effectively slowing the functional decline associated with aging.

Biological Time Deceleration

Meaning

Biological Time Deceleration is a scientific and clinical concept describing the slowing of the intrinsic rate of aging at the cellular and molecular level, measured independently of chronological age. This deceleration is quantified by biomarkers of aging, such as epigenetic clocks or telomere length, reflecting an improved functional state and reduced allostatic load. The objective is to extend healthspan by mitigating the biological wear and tear that predisposes individuals to age-related pathologies.