The continuous, adaptive stewardship of the body’s interconnected physiological processes, with a focus on maintaining homeostasis and resilience across the lifespan. This management necessitates a deep understanding of the interplay between the nervous, immune, and endocrine systems. It is the practical application of clinical science to daily living.
Origin
This concept evolved from early systems theory applied to physiology, recognizing that single-organ interventions often fail due to systemic interdependence. In endocrinology, it acknowledges that the pituitary, thyroid, and gonadal axes do not operate in isolation. Effective management requires a holistic, integrated perspective.
Mechanism
Management operates through iterative feedback loops, utilizing data to adjust inputs that influence endocrine output and cellular response fidelity. For example, optimizing cortisol clearance rates indirectly supports insulin sensitivity and reproductive hormone regulation. This process seeks to dampen inflammatory signals that disrupt normal regulatory setpoints.
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