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Biological Signaling Fidelity

Meaning

Biological Signaling Fidelity refers to the accuracy, clarity, and responsiveness of the communication pathways within and between cells, particularly those involving hormones and neurotransmitters. High fidelity ensures that a hormonal message, such as an insulin or testosterone signal, is correctly received, transduced, and acted upon by the target cell without interference or degradation. Diminished fidelity, often seen with aging or chronic disease, manifests as receptor desensitization or impaired post-receptor signaling, leading to functional hormonal resistance. Maintaining this precision is fundamental for optimal physiological regulation and health.