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Biological Setpoints

Meaning

Biological Setpoints are the internally regulated, homeostatic target values for various physiological parameters, such as core body temperature, blood glucose concentration, or basal hormone levels. These setpoints are dynamically maintained by complex feedback loops within the neuroendocrine system and are essential for sustaining health and stability. While genetically influenced, these regulatory thresholds can drift or become dysregulated due to chronic stress, aging, or disease states, leading to functional decline. Clinical practice in longevity medicine often seeks to recalibrate these setpoints toward a more youthful, optimal range.