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Biological Set-Point Redefinition

Meaning

The process of clinically and behaviorally shifting the homeostatic regulatory target, or set-point, for critical physiological parameters away from a suboptimal, disease-promoting equilibrium toward a more optimal, health-promoting state. In endocrinology, this frequently involves recalibrating targets for insulin sensitivity, body fat distribution, or circulating hormone concentrations. It acknowledges that the body often defends a “set-point” that may not align with maximal longevity or performance. This redefinition requires persistent external input to override established internal physiological inertia.