The clinical strategy aimed at maximizing the functional capacity and redundancy within the body’s physiological systems, particularly the endocrine and metabolic pathways, to better withstand stressors.
Origin
This concept emerges from systems biology and gerontology, where “biological reserve” quantifies the margin of function above the minimum required for basic survival, and “optimization” seeks to enhance this buffer.
Mechanism
Optimization is achieved through targeted interventions that improve cellular efficiency, reduce allostatic load, and support key regulatory feedback mechanisms, thereby increasing the system’s ability to recover from perturbation.
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