The clinical objective of prolonging the period of optimal human physiological function and healthspan, rather than merely extending chronological lifespan. This concept focuses on maintaining robust hormonal balance, cellular integrity, and high-level metabolic efficiency well beyond typical age-related decline. It represents a state where biological age significantly lags behind chronological age, driven by proactive clinical management.
Origin
This term is a conceptual construct arising from the intersection of geroscience, preventative medicine, and advanced anti-aging endocrinology. Its foundation lies in the medical shift from reactive disease treatment to proactive optimization of biological systems, specifically leveraging advancements in hormonal modulation. The underlying principle draws from longevity research which seeks to compress morbidity into the final years of life.
Mechanism
Achievement relies on the precise modulation of key endocrine axes, including the somatotropic, gonadal, and thyroid systems, alongside meticulous metabolic control. This involves optimizing hormone levels to youthful ranges and implementing interventions that enhance mitochondrial function and cellular repair pathways. The sustained maintenance of youthful tissue function and systemic homeostasis is the primary mechanism of action.
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