The deliberate clinical and lifestyle manipulation of gene expression and cellular signaling pathways to influence health outcomes, primarily through epigenetic and environmental factors. This concept moves beyond simply measuring biomarkers to actively steering the body’s internal biological programming toward a state of optimal function and resilience. It is the application of molecular biology principles to personalized health and longevity.
Origin
This term is derived from the convergence of molecular biology, epigenetics, and nutritional genomics, where the focus shifted from the fixed DNA sequence to the dynamic regulation of gene activity. ‘Control’ emphasizes the therapeutic goal of influencing the translation of genetic potential into actual physiological function.
Mechanism
The primary mechanism involves utilizing specific inputs, such as targeted micronutrients, hormonal signals, and controlled environmental stressors, to influence transcription factors and chromatin remodeling. These inputs modify the epigenetic landscape, altering the rate at which certain genes are transcribed into functional proteins. Effective control ensures the preferential expression of genes associated with cellular repair, metabolic efficiency, and anti-inflammatory responses.
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