What is the Origin of Biological Decay?

The concept of biological decay is rooted in the foundational principles of gerontology and the thermodynamic laws applied to living systems. The term reflects the cumulative impact of intrinsic and extrinsic stressors on the human organism. It serves as a clinical descriptor for the net negative outcome of aging processes.

What is the Mechanism of Biological Decay?

The core mechanism involves the accumulation of molecular and cellular damage, including oxidative stress, mitochondrial DNA mutations, and impaired proteostasis. Hormonal shifts, such as the age-related decrease in anabolic hormones and relative increase in catabolic signaling, significantly accelerate this decay. Ultimately, this leads to tissue and organ dysfunction, manifesting as age-associated pathology.

Biological Decay ∞ Area

Biological Decay

Meaning

The progressive, inevitable decline in the functional capacity and structural integrity of an organism’s biological systems over time. This decline is characterized by a reduced ability to maintain homeostasis and repair molecular damage, leading to increased vulnerability to disease. It represents the measurable deterioration of physiological reserves and cellular vitality.