These are the specific physiological parameters or internal states that the body actively regulates to maintain dynamic equilibrium, or homeostasis, within narrow, functional ranges. In the context of hormonal health, these variables include core body temperature, blood glucose levels, and the circulating concentrations of critical hormones like cortisol and thyroid hormones. Precise control of these factors is necessary for optimal cellular function.
Origin
Stemming from systems theory applied to physiology, the term describes elements subject to negative or positive feedback loops managed by the central nervous system and the endocrine system. The “variable” aspect emphasizes that these values fluctuate but must remain within defined operational limits. This framework is essential for understanding feedback mechanisms in endocrinology.
Mechanism
Control is executed via sensory input detecting deviations from a set point, followed by effector responses mediated primarily through hormonal release or neural signaling. For example, the hypothalamic-pituitary-adrenal (HPA) axis modulates the biological variable of systemic stress response via cortisol secretion. Quantifying the deviation and the speed of correction defines the robustness of the control mechanism.
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