Biological Clock Reset is the acute, often rapid, adjustment of the body’s central and peripheral circadian oscillators following a significant disruption to the normal light-dark or feeding schedule. Clinically, this intervention is necessary after severe jet lag or shift work to restore synchronized endocrine signaling. A successful reset re-establishes optimal temporal coordination of physiological functions.
Origin
This terminology is borrowed from the study of chronodisruption, describing the necessary corrective action required when environmental timing cues deviate sharply from the established endogenous rhythm. In health science, it highlights the plasticity of the circadian system in response to acute environmental shifts. It signifies a deliberate re-phasing event.
Mechanism
A reset is typically triggered by strong, phase-shifting zeitgebers, most potently bright light exposure at specific biological times or strategic meal timing relative to the previous cycle’s end. These cues override the existing molecular oscillations within the SCN neurons, leading to a shift in the expression profile of clock genes. This shift propagates to peripheral tissues, recalibrating daily patterns of hormone release and substrate utilization.
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