A clinical and physiological concept describing the restoration of a compromised biological system to a state approximating its optimal, pre-stress, or youthful functional capacity. This process involves systematically addressing underlying chronic stressors, inflammation, and metabolic dysregulation to recalibrate key homeostatic set points. The goal is not merely symptom management but a fundamental structural and functional recalibration of the endocrine and metabolic systems.
Origin
The term is derived from systems biology and chronobiology, where a “baseline” refers to the fundamental state of an organism’s internal environment, often measured by key biomarkers. The “Reset” component reflects the clinical objective of re-establishing optimal diurnal rhythms, hormonal pulsatility, and metabolic flexibility, which are often disrupted by modern lifestyle factors and chronic stress.
Mechanism
The reset mechanism targets the central regulatory axes, such as the Hypothalamic-Pituitary-Adrenal (HPA) and Hypothalamic-Pituitary-Gonadal (HPG) axes, to restore proper feedback loops. Interventions often focus on optimizing sleep architecture to enhance nocturnal repair cycles and leveraging nutritional timing to improve insulin sensitivity and mitochondrial function. This dual action of central nervous system recalibration and peripheral metabolic optimization drives the systemic functional recovery.
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