The inherent physiological capacity of a biological system to not merely withstand stressors, but to actually improve, adapt, or become stronger when subjected to controlled, intermittent challenges. This concept extends beyond simple resilience, indicating a positive structural or functional gain following perturbation. In endocrinology, this relates to how systems like the HPA axis respond to hormetic stressors.
Origin
This term originates from Nassim Nicholas Taleb’s concept of antifragility, adapted here for the physiological context of human health science. Its application in wellness science posits that certain mild physiological disruptions can enhance system robustness. We look at how biological networks actively benefit from disorder rather than just surviving it.
Mechanism
Antifragility operates through adaptive responses, such as inducing beneficial molecular chaperones or optimizing cellular repair pathways in response to mild, controlled challenges. For instance, appropriate exercise or intermittent fasting can trigger cellular processes that enhance metabolic efficiency and hormonal sensitivity. The system actively reorganizes its architecture to better handle future, potentially larger, demands.
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