Biological Aging Reversal describes the theoretical and emerging clinical objective of turning back the physiological clock by targeting the fundamental hallmarks of senescence. This is not merely slowing aging but actively restoring cellular function toward a younger state, often assessed through epigenetic clocks or telomere length. Achieving true reversal requires sophisticated intervention across multiple biological systems simultaneously. We approach this concept with scientific rigor, understanding the complexity of systemic decline.
Origin
The concept builds upon gerontology, moving beyond simple lifespan extension to focus on healthspan extension through intrinsic biological modification. ‘Reversal’ implies a dynamic process of regeneration rather than mere maintenance. The term reflects the cutting edge of longevity research intersecting with cellular reprogramming technologies.
Mechanism
Potential mechanisms involve the targeted modification of the epigenome, perhaps through controlled Yamanaka factor induction or demethylation strategies to reset cellular identity. Furthermore, this may include clearing senescent cells via senolytics or restoring proteostasis balance within the cell. Effective reversal protocols must address genomic instability and mitochondrial dysfunction simultaneously to yield systemic benefits.
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