The proactive, clinical strategy focused on influencing the rate and direction of an individual’s biological aging process, as distinct from chronological age. This approach utilizes advanced biomarkers and physiological assessments to quantify the speed of aging. The primary goal is to slow, stabilize, or, ideally, reverse the trajectory of biological decline. Personalized interventions in endocrinology, nutrition, and lifestyle are integral to optimizing cellular function and systemic resilience.
Origin
This concept originates from the convergence of gerontology, epigenetics, and preventative medicine, gaining clinical relevance with the development of accurate biological age clocks. The term reflects a necessary shift from merely treating age-related disease to actively managing the underlying aging process itself. It formalizes the application of longevity science within a sophisticated clinical wellness framework.
Mechanism
Management operates by targeting the recognized hallmarks of aging, such as telomere attrition, mitochondrial dysfunction, and cellular senescence. Hormonal optimization, including balancing growth factors and sex steroids, plays a crucial role in maintaining tissue integrity and signaling pathways. By modulating these molecular mechanisms, the intervention aims to preserve physiological reserve and extend the healthspan.
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