The longitudinal process of monitoring an individual’s estimated biological age, which reflects the functional and cellular integrity of their body, in contrast to their chronological age. This tracking involves repeated measurement of specific biomarkers, including epigenetic, proteomic, or physiological indices, over time. It provides a dynamic, actionable assessment of aging rate and the efficacy of longevity-focused interventions.
Origin
Biological age tracking has its foundation in the field of gerontology, evolving from early attempts using simple physiological markers to the sophisticated molecular clocks of modern science. The need for a metric that better predicts healthspan and mortality than chronological age drove the development of these tools. This systematic approach allows for personalized, data-driven optimization of health and longevity.
Mechanism
The mechanism relies on algorithms that integrate data from multiple biological systems to generate a single metric of biological age. Key biomarkers, such as DNA methylation status at specific CpG sites, telomere length, or specific blood chemistry markers, are measured and weighted. By observing the trend of this calculated age, clinicians can ascertain whether a patient’s physiological trajectory is accelerating, decelerating, or reversing the aging process.
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