A set of measurable physiological parameters, distinct from chronological age, used to track the degree to which interventions have successfully decelerated or reversed age-associated molecular and functional deterioration. These metrics often include assessments of DNA methylation patterns, telomere dynamics, and systemic inflammatory markers. The goal is to quantify functional rejuvenation at the tissue level.
Origin
This field draws heavily from epigenetic research and advances in understanding cellular senescence pathways. The term signifies a commitment to intervening in the aging process based on molecular biology rather than calendar years. It represents a modern clinical focus on extending vitality through targeted physiological adjustments.
Mechanism
Reversal mechanisms often target epigenetic reprogramming, influencing gene expression profiles associated with youthfulness and cellular repair capacity. Supporting optimal endocrine signaling, particularly through robust sex hormone and DHEA levels, aids in cellular repair processes. Enhancing nutrient delivery to mitochondria directly supports the energy required for these complex restorative actions.
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