Clinical strategies to reduce an individual’s calculated biological age relative to their chronological age, targeting the underlying molecular and cellular processes of senescence. This represents a measurable shift in physiological function toward a younger, more resilient state. It is the practical application of longevity science to optimize systemic vitality.
Origin
The concept stems from the interdisciplinary field of gerontology and biogerontology, focusing on the distinction between time lived, which is chronological age, and the functional capacity of the body’s systems, which is biological age. Its clinical relevance has exponentially grown with the development of quantitative epigenetic clocks and other sophisticated biomarkers of aging.
Mechanism
Modification is achieved through targeted interventions that influence key biological hallmarks, such as optimizing endocrine signaling pathways, improving mitochondrial function, and modulating epigenetic markers like DNA methylation. These actions aim to enhance cellular repair mechanisms and systemic homeostasis. By addressing the root causes of cellular decline, the intervention effectively slows the rate of biological deterioration.
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