Bioidentical Hormones are compounds that are chemically and structurally identical to the hormones naturally produced by the human body, such as estradiol, progesterone, testosterone, and DHEA. Unlike synthetic hormones, which possess altered chemical structures, bioidenticals are designed to interact with hormone receptors precisely as endogenous hormones do. This structural congruence is believed to facilitate a more natural physiological response and integration within the endocrine system.
Origin
The concept traces back to the early 20th century with the isolation and synthesis of steroid hormones from plant sources, such as yams and soy. The clinical application gained traction in the latter half of the century as practitioners sought hormone replacement options that more closely mirrored the body’s native chemistry. The term “bioidentical” emphasizes this exact molecular match to human hormones.
Mechanism
Bioidentical Hormones exert their effects by binding directly and specifically to their cognate nuclear and membrane receptors within target cells. Once bound, the hormone-receptor complex translocates to the cell nucleus, where it modulates gene expression, initiating the synthesis of specific proteins and cellular functions. Because the molecular structure is identical to the native hormone, the body’s metabolic pathways recognize and process them naturally, leading to predictable downstream hormonal effects.
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