The clinical utilization of exogenous hormones chemically identical to those naturally produced by the human body, such as estradiol, progesterone, or testosterone, to address deficiencies or imbalances. Application is strictly guided by diagnostic assessment of individual endocrine profiles and symptomatic presentation. This approach emphasizes physiological relevance in therapeutic dosing and formulation selection.
Origin
Rooted in the evolution of hormone replacement therapy, this term distinguishes itself by focusing on molecular structure matching endogenous compounds. The application science draws heavily from pharmaceutical compounding principles integrated with established endocrinological dosing standards. Its history involves the refinement of delivery systems to mimic natural secretion patterns.
Mechanism
Bioidentical application works by engaging native steroid receptors within target cells, promoting downstream genomic and non-genomic actions characteristic of physiological hormones. Proper application ensures receptor saturation without supraphysiological fluctuations that can lead to adverse downstream effects. Effective implementation requires continuous monitoring of serum and sometimes salivary hormone metabolites to confirm therapeutic targets are met.
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