A therapeutic plan employing hormones that are chemically indistinguishable from those naturally synthesized by the human body for endocrine support. This strategy is focused on restoring physiological balance rather than introducing foreign molecular structures. We aim for receptor interaction that mimics endogenous signaling patterns. This approach is distinct from using synthetic analogues with altered receptor profiles.
Origin
The concept stems from endocrinology’s recognition that synthetic hormones often possess differing pharmacokinetics and receptor binding characteristics. The term ‘bioidentical’ underscores the structural congruence with endogenous compounds like estradiol or testosterone. This perspective arose from the desire to achieve highly specific physiological effects with minimal off-target activity.
Mechanism
The strategy functions by providing precursors or the hormones themselves that bind precisely to native cellular receptors. This precise interaction facilitates normal signal transduction cascades within target tissues. Through careful dosing, the aim is to maintain circulating levels within the optimal physiological range for target organs. This supports processes like bone mineralization and cognitive function dependent on native receptor occupancy.
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