What is the Origin of Bioidentical Hormone Sequencing?

This term originates from the compounding pharmacy and functional medicine movement, emphasizing structural identity ("bioidentical") with synthetic hormones. 'Sequencing' reflects the application of chronobiology, recognizing that hormone replacement requires rhythmic, time-dependent administration. It contrasts sharply with older, high-dose, continuous hormone replacement paradigms.

What is the Mechanism of Bioidentical Hormone Sequencing?

The mechanism relies on leveraging hormone receptor dynamics which are optimized by cyclical exposure. For example, sequencing may involve timing estrogen and progesterone administration to replicate the follicular and luteal phases. This strategy aims to maintain target tissue responsiveness while avoiding the desensitization often seen with static dosing protocols. Proper sequencing supports the body's natural endocrine rhythms, promoting physiological balance.

Bioidentical Hormone Sequencing ∞ Area

Bioidentical Hormone Sequencing

Meaning

A therapeutic strategy involving the precise timing and combination of administering hormones structurally identical to those naturally produced by the human body. This approach seeks to mimic endogenous pulsatile secretion patterns rather than maintaining constant supra-physiological levels. The goal is to optimize receptor sensitivity and minimize negative feedback loops.