The clinical delivery of hormones chemically identical to those naturally produced by the human body, such as estradiol or testosterone, often tailored to individual serum levels. This approach seeks physiological restoration rather than simple replacement by matching endogenous molecular structures.
Origin
Etymologically, “bioidentical” signifies molecules structurally matching endogenous compounds, while “administration” denotes the prescribed method of delivery into the physiological system. It reflects a philosophy rooted in mimicking natural endocrine profiles.
Mechanism
These hormones interact with specific nuclear receptors on target cells, initiating transcription of genetic material that promotes downstream cellular responses, thereby supporting normal endocrine function and metabolic balance. The mechanism relies on the body’s inherent receptor machinery recognizing the administered compound as its natural ligand.
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