The systematic application of interventions derived from longevity science to intentionally slow, halt, or partially reverse the physiological manifestations of biological aging. This is a proactive clinical strategy focused on maintaining functional capacity and delaying age-related disease onset. We seek to optimize cellular maintenance systems.
Origin
This term synthesizes the practice of “biohacking”—self-directed self-improvement through technology and biology—with the established scientific study of aging, or senescence. It represents a contemporary, interventionist stance toward managing the trajectory of human lifespan. The goal is to maintain youthful endocrine and metabolic function longer.
Mechanism
Interventions commonly focus on modulating core aging pathways, such as targeting senescent cells via senolytics or optimizing nutrient sensing pathways like mTOR and AMPK. By influencing DNA repair mechanisms and mitigating chronic low-grade inflammation (inflammaging), we attempt to restore cellular homeostasis. This directly impacts the signaling cascades that govern tissue turnover and hormonal responsiveness.
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