The application of biological, genetic, and physiological principles to intentionally manipulate the underlying molecular processes that drive cellular senescence and organismal decline. This approach involves precise lifestyle, nutritional, and pharmacological interventions aimed at slowing or reversing the biological clock, moving beyond chronological age as the sole measure of health. It focuses on optimizing cellular environments to maintain peak function and resilience against age-related hormonal dysregulation and tissue degradation.
Origin
The term “biohacking” emerged from the intersection of biology and “hacker culture” in the early 21st century, representing a do-it-yourself biology movement. When combined with “cellular aging,” it grounds the broad concept in the specific scientific domain of geroscience and endocrinology. This fusion reflects a modern, proactive paradigm shift from simply treating disease to actively engineering biological longevity and vitality.
Mechanism
Mechanisms target the Hallmarks of Aging, including mitochondrial dysfunction, telomere shortening, epigenetic alterations, and impaired cellular signaling pathways like mTOR and AMPK. Hormonal optimization plays a crucial role, ensuring endocrine balance to support cellular repair and metabolic homeostasis. By strategically modulating these molecular control pathways, the goal is to enhance cellular integrity, promote autophagy, and sustain youthful physiological function.
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