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Bioenergetic Switching

Meaning

Bioenergetic Switching refers to the physiological capacity of cells and tissues to rapidly and efficiently transition between different primary fuel sources, typically shifting from glucose-based glycolysis to fatty acid oxidation or ketone utilization. This essential metabolic flexibility is a hallmark of robust health and efficient energy homeostasis, allowing the body to adapt to varying nutritional states, such as fasting or intense exercise. Impaired switching is a significant factor in metabolic syndrome and insulin resistance, underscoring its clinical importance.