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Bioenergetic Failure

Meaning

Bioenergetic Failure describes a clinical state characterized by the profound inability of the body’s cellular machinery, primarily the mitochondria, to produce sufficient adenosine triphosphate (ATP) to meet the energetic demands of essential physiological processes. This impairment leads to systemic dysfunction, affecting high-energy-demand organs like the brain, heart, and skeletal muscle, resulting in symptoms such as chronic fatigue and reduced organ function. It is a critical endpoint in various chronic diseases and age-related decline, reflecting a collapse in cellular energy metabolism.